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Current Guidelines for GLP-1 Agonists During Pregnancy Medical organizations and regulatory bodies do not recommend the use of GLP-1 receptor agonists, including Semaglutide, during pregnancy due to these potential risks

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----When a pregnancy is recognized, the patient should be apprised of the risk to the fetus

Similarly, deleting GLP-1Rs in the VMH does not prevent the inhibitory effects of chronic systemic exendin-4 and liraglutide on food intake and body weight [132]